Ferdinand Robert F, de Nijs Pieter F A, van Lier Pol, Verhulst Frank C
Department of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam, The Netherlands.
J Affect Disord. 2005 Nov;88(3):299-306. doi: 10.1016/j.jad.2005.08.004. Epub 2005 Sep 22.
Comorbidity between anxiety disorders and depressive disorders in adolescents occurs very frequently. The aim of this study was to investigate if anxiety and depression represent distinct disease entities.
Two thousand thirty two 11- to 18-year-olds, referred to mental health services, were investigated. Self-reported symptoms of anxiety and depression were analyzed with latent class analysis.
The numbers of adolescents with severe depression symptoms, but with less severe, or absent, anxiety symptoms, were negligible. Further, two subgroups could be discerned in those with severe anxiety symptoms: one with severe depressive symptoms, and one with mild depressive symptoms.
A self-report questionnaire was used, whereas diagnostic interview information regarding DSM-IV disorders was not available.
It seems less useful to develop treatments, or to conduct studies aimed at etiological mechanisms, that are specifically aimed at depression and not at anxiety. Further, it may be relevant to discern specific subgroups of anxious adolescents, with severe versus mild comorbid depression symptoms.
青少年焦虑症和抑郁症之间的共病情况非常常见。本研究的目的是调查焦虑和抑郁是否代表不同的疾病实体。
对转介至心理健康服务机构的2032名11至18岁青少年进行了调查。采用潜在类别分析对自我报告的焦虑和抑郁症状进行分析。
有严重抑郁症状但焦虑症状较轻或无焦虑症状的青少年人数可忽略不计。此外,在有严重焦虑症状的青少年中可辨别出两个亚组:一个有严重抑郁症状,另一个有轻度抑郁症状。
使用的是自我报告问卷,而关于DSM-IV障碍的诊断访谈信息不可用。
开发专门针对抑郁症而非焦虑症的治疗方法或针对病因机制的研究似乎用处不大。此外,区分有严重与轻度共病抑郁症状的焦虑青少年的特定亚组可能具有相关性。