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短期输尿管支架置入预防肾移植术后泌尿系统并发症的优势:18年经验总结

Advantages of short-time ureteric stenting for prevention of urological complications in kidney transplantation: an 18-year experience.

作者信息

Sansalone C V, Maione G, Aseni P, Mangoni I, Soldano S, Minetti E, Radaelli L, Civati G

机构信息

Kidney and Pancreas Transplantation Unit, Niguarda Hospital, Milan, Italy.

出版信息

Transplant Proc. 2005 Jul-Aug;37(6):2511-5. doi: 10.1016/j.transproceed.2005.06.035.

Abstract

We retrospectively studied the incidence of urological complications in a consecutive series of 590 patients (group B) who received a kidney transplant (KT) with a ureteral stent from January 1994 to December 2002. The ureteral stent was sewn to the bladder catheter during the surgical procedure and left in situ for a mean time of 10 days (range 8 to 12 days). The results were compared to a consecutive series of 414 patients who received a KT from March 1986 to December 1993 without a ureteral stent (group A). The two groups were comparable in terms of donor and recipient gender, ischemia time, delayed graft function, and chronic rejection incidence, but differed in mean donor age (44.1 vs 36.0 years), mean recipient age (45.4 vs 39.1 years), living/cadaveric donor rate (19.8% vs 11.9%), arterial lesions and bench reconstruction rate (11.1 vs 3.5%), as well as acute rejection episodes (11.7% vs 29.2%). Complications were seen in nine patients in group B (1.5%) and 17 patients in group A (4.1%) (P < .0001). Urinary leaks presented in two patients in group B (0.3%) and 11 patients in Group A (2.6%; P < .0001), while stenosis was present in six patients in group B (1.5%) and 7 in group A (1.2%) (P = NS). Urological complications such as urinary tract infection and macroscopic hematuria were similar in both groups. Time to presentation of a leak was within 2 weeks from KT in 10 patients (92.3%), while stenosis presented early in four patients (one in group B and four in group A). Of the stenoses, 69.3% presented late (beyond 12 weeks) in five patients in group B and three in Group A. In conclusion, our data suggest that routine use of double pigtail ureteral stent significantly decreased the incidence of leaks and early stenoses, but it did not modify late stenosis incidence. In the last decade, risk factors for urological complications have been increasing over time, namely, older donors and older recipients, living donation, length of dialysis, and the use of grafts with arterial lesions. Therefore we believe that a ureteral stent should be routinely considered to afford the advantage to protect the urinary anastomosis in the early postoperative period when the incidence of complications is highest, without the need of cystoscopy for its removal.

摘要

我们回顾性研究了1994年1月至2002年12月期间连续590例接受带输尿管支架肾移植(KT)患者(B组)的泌尿系统并发症发生率。手术过程中输尿管支架缝在膀胱导管上,原位留置平均10天(范围8至12天)。将结果与1986年3月至1993年12月期间连续414例未使用输尿管支架接受KT的患者(A组)进行比较。两组在供体和受体性别、缺血时间、移植肾功能延迟及慢性排斥发生率方面具有可比性,但在供体平均年龄(44.1岁对36.0岁)、受体平均年龄(45.4岁对39.1岁)、活体/尸体供体率(19.8%对11.9%)、动脉病变及台上重建率(11.1对3.5%)以及急性排斥反应发生率(11.7%对29.2%)方面存在差异。B组9例患者(1.5%)和A组17例患者(4.1%)出现并发症(P<0.0001)。B组2例患者(0.3%)和A组11例患者(2.6%;P<0.0001)出现尿漏,而B组6例患者(1.5%)和A组7例患者(1.2%)出现狭窄(P=无统计学意义)。两组泌尿系统感染和肉眼血尿等泌尿系统并发症相似。10例患者(92.3%)尿漏出现在KT后2周内,而4例患者(B组1例,A组4例)早期出现狭窄。在狭窄患者中

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