松果体切除对大鼠杏仁核点燃发展的影响。

Influence of pinealectomy on the amygdala kindling development in rats.

作者信息

Janjoppi Luciana, Silva de Lacerda Aline Fabiana, Scorza Fulvio Alexandre, Amado Debora, Cavalheiro Esper Abrão, Arida Ricardo Mario

机构信息

Laboratório de Neurologia Experimental, Universidade Federal de São Paulo-Escola Paulista de Medicina, UNIFESP/EPM, Rua Botucatú 862, Vila Clementino, Brazil.

出版信息

Neurosci Lett. 2006 Jan 9;392(1-2):150-3. doi: 10.1016/j.neulet.2005.09.009. Epub 2005 Sep 23.

DOI:10.1016/j.neulet.2005.09.009

PMID:16183197

Abstract

A considerable number of studies have demonstrated the anticonvulsant effect of melatonin. The present study examines the influence of pinealectomy on the amygdala kindling development in rats. Animals were divided into three groups: Pinealectomized rats (PNT) Sham rats (SHAM) and Control rats (CTL). The mean number of stimulations and the afterdischarge (AD) duration for each stage of kindling were similar among CTL and SHAM animals. Conversely, PNT animals showed particular characteristics during kindling development. They did not present stage 1 and spent a shorter time in stage 2 in relation to the CTL and SHAM animals. Consequently, the number of stimulations required to reach stage 5 was lower for the PNT group when compared to the CTL and SHAM groups. Besides, a longer AD duration during stage 5 in the PNT group was also observed. The present findings indicate that the pineal gland removal exert a significant influence on amygdala kindling development suggesting that melatonin holds potential interest in experimental therapy for epilepsy.

摘要

大量研究已证实褪黑素具有抗惊厥作用。本研究考察松果体切除对大鼠杏仁核点燃发展的影响。动物被分为三组：松果体切除大鼠（PNT）、假手术大鼠（SHAM）和对照大鼠（CTL）。CTL和SHAM动物在点燃各阶段的平均刺激次数和后放电（AD）持续时间相似。相反，PNT动物在点燃发展过程中表现出特殊特征。与CTL和SHAM动物相比，它们没有出现第1阶段，且在第2阶段花费的时间更短。因此，与CTL组和SHAM组相比，PNT组达到第5阶段所需的刺激次数更少。此外，还观察到PNT组在第5阶段的AD持续时间更长。目前的研究结果表明，切除松果体对杏仁核点燃发展有显著影响，提示褪黑素在癫痫实验治疗中具有潜在价值。