Flaherty Keith T, Fuchs Charles S, Colditz Graham A, Stampfer Meir J, Speizer Frank E, Willett Walter C, Curhan Gary C
Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Cancer Causes Control. 2005 Nov;16(9):1099-106. doi: 10.1007/s10552-005-0349-8.
We prospectively investigated the independent association of hypertension, thiazide use, body mass index, weight change, and smoking with the risk of renal cell carcinoma among men and women using biennial mailed questionnaires.
The study population included 118,191 women participating in the Nurses' Health Study and 48,953 men participating in the Health Professionals Follow-up Study.
During 24 years of follow-up for women and 12 years for men, 155 and 110 incident cases of renal cell carcinoma were confirmed, respectively. In multivariate models including age, body mass index (BMI), smoking and hypertension, higher BMI was confirmed as a risk factor for women and smoking as a risk factor for men and women. After adjusting for age, updated BMI and smoking, an updated diagnosis of hypertension was associated with renal cell carcinoma (RCC); the relative risk (RR) was 1.9 (95% CI 1.4-2.7) for women and 1.8 (95% CI 1.2-2.7) for men. Based on limited data regarding the use of thiazide diuretics, we did not observe a risk associated with their use, independent of the diagnosis of hypertension.
Diagnosis of hypertension, higher BMI, and increasing pack-years of smoking appear to independently increase the risk of renal cell carcinoma.
我们使用两年期邮寄问卷，前瞻性地研究了高血压、噻嗪类药物使用、体重指数、体重变化和吸烟与男性和女性肾细胞癌风险之间的独立关联。
研究人群包括118191名参与护士健康研究的女性和48953名参与卫生专业人员随访研究的男性。
在对女性进行24年随访和对男性进行12年随访期间，分别确诊了155例和110例肾细胞癌新发病例。在包括年龄、体重指数（BMI）、吸烟和高血压的多变量模型中，较高的BMI被确认为女性的危险因素，吸烟被确认为男性和女性的危险因素。在调整年龄、更新的BMI和吸烟因素后，高血压的最新诊断与肾细胞癌（RCC）相关；女性的相对风险（RR）为1.9（95%CI 1.4 - 2.7），男性为1.8（95%CI 1.2 - 2.7）。基于关于噻嗪类利尿剂使用的有限数据，我们未观察到其使用独立于高血压诊断之外的风险。
高血压诊断、较高的BMI以及吸烟包年数增加似乎独立增加肾细胞癌风险。
