病毒衣壳组装的理论方面。

Theoretical aspects of virus capsid assembly.

作者信息

Zlotnick Adam

机构信息

Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

出版信息

J Mol Recognit. 2005 Nov-Dec;18(6):479-90. doi: 10.1002/jmr.754.

DOI:10.1002/jmr.754

PMID:16193532

Abstract

A virus capsid is constructed from many copies of the same protein(s). Molecular recognition is central to capsid assembly. The capsid protein must polymerize in order to create a three-dimensional protein polymer. More than structure is required to understand this self-assembly reaction: one must understand how the pieces come together in solution.

摘要

病毒衣壳由相同蛋白质的多个拷贝构建而成。分子识别是衣壳组装的核心。衣壳蛋白必须聚合以形成三维蛋白质聚合物。要理解这种自组装反应，所需的不仅仅是结构知识：还必须了解这些片段在溶液中是如何聚集在一起的。