鼠链球菌BHT菌株可产生一种I类双组分羊毛硫抗生素和一种II类细菌素。
Streptococcus rattus strain BHT produces both a class I two-component lantibiotic and a class II bacteriocin.
作者信息
Hyink Otto, Balakrishnan Mayooran, Tagg John R
机构信息
Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
出版信息
FEMS Microbiol Lett. 2005 Nov 15;252(2):235-41. doi: 10.1016/j.femsle.2005.09.003. Epub 2005 Sep 19.
Streptococcus rattus strain BHT is a species representative and strong bacteriocin producer. Here we report that S. rattus BHT produces two quite different types of bacteriocin activity, named BHT-A and BHT-B. The two bacteriocins were purified and analysed for activity and by MALDI-TOF mass spectrophotometry. BHT-A was found to be a variant of the two-component lantibiotic, Smb. BHT-B is a non-modified 5195Da peptide with some similarity to the tryptophan-rich Staphylococcus aureus bacteriocin, aureocin A53. Six S. rattus and two S. mutans strains were found to contain both the BHT-A and BHT-B genetic loci.
鼠链球菌BHT菌株是一种具有代表性且能高效产生细菌素的菌株。在此我们报告，鼠链球菌BHT产生两种截然不同的细菌素活性，分别命名为BHT - A和BHT - B。对这两种细菌素进行了纯化，并分析了其活性，同时采用基质辅助激光解吸电离飞行时间质谱法进行分析。发现BHT - A是双组分羊毛硫抗生素Smb的一个变体。BHT - B是一种未修饰的5195Da肽，与富含色氨酸的金黄色葡萄球菌细菌素aureocin A53有一定相似性。发现6株鼠链球菌和2株变形链球菌菌株同时含有BHT - A和BHT - B基因位点。
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