在一个简单模型中，介质对折叠成稳定蛋白质的序列选择的影响。
Medium effects on the selection of sequences folding into stable proteins in a simple model.
作者信息
Li You-Quan, Ji Yong-Yun, Mao Jun-Wen, Tang Xiao-Wei
机构信息
Department of Physics, Zhejiang University, Hangzhou 310027, People's Republic of China.
出版信息
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Aug;72(2 Pt 1):021904. doi: 10.1103/PhysRevE.72.021904. Epub 2005 Aug 16.
PMID:16196601
Abstract
We study the medium effects on the selection of sequences in protein folding by taking into account surface potential in hydrophobic-polar model. Our numerical calculation demonstrates that the surface potential enhances the average gap for the highly designable structures. It also shows that the most stable structure may be no longer the most stable one if the medium is changed.
摘要
我们通过在疏水-极性模型中考虑表面电势来研究介质对蛋白质折叠中序列选择的影响。我们的数值计算表明，表面电势增加了高度可设计结构的平均间距。计算还表明，如果介质发生变化，最稳定的结构可能不再是最稳定的结构。
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