脑缺血的正电子发射断层扫描成像

Positron emission tomography imaging of cerebral ischemia.

作者信息

Derdeyn Colin P

机构信息

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Neuroimaging Clin N Am. 2005 May;15(2):341-50, x-xi. doi: 10.1016/j.nic.2005.05.001.

DOI:10.1016/j.nic.2005.05.001

PMID:16198944

Abstract

Positron emission tomography (PET) uniquely allows the in vivo regional measurement of several important physiologic parameters in living humans, including cerebral blood flow and oxygen metabolism. PET studies have advanced our understanding of normal human brain physiology and, as detailed in this article, our understanding of human cerebrovascular pathophysiology. This article focuses on knowledge gained from PET regarding acute ischemic stroke and chronic oligemia from arterial occlusive disease. Knowledge of the responses of the brain and its vasculature to ischemia and oligemia is growing more important with the increasing availability of CT and MR perfusion techniques.

摘要

正电子发射断层扫描（PET）独特地允许在活体人类中对几种重要的生理参数进行体内区域测量，包括脑血流量和氧代谢。PET研究增进了我们对正常人类脑生理学的理解，并且如本文所详述，也增进了我们对人类脑血管病理生理学的理解。本文重点关注从PET获得的关于急性缺血性中风和动脉闭塞性疾病所致慢性低灌注的知识。随着CT和MR灌注技术的日益普及，了解大脑及其血管对缺血和低灌注的反应变得越来越重要。