联芳基二酰胺作为强效促黑素聚集激素受体1拮抗剂。
Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists.
作者信息
Palani Anandan, Shapiro Sherry, McBriar Mark D, Clader John W, Greenlee William J, O'Neill Kim, Hawes Brian
机构信息
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
出版信息
Bioorg Med Chem Lett. 2005 Dec 1;15(23):5234-6. doi: 10.1016/j.bmcl.2005.08.043. Epub 2005 Oct 3.
Herein, we report the discovery of the potent and selective biaryl diamide derived MCH-R1 receptor antagonist 1, which was identified upon modification of a previously disclosed biaryl urea series. This paper describes one of the strategies incorporated to remove the highly mutagenic biarylaniline present in an otherwise promising biaryl urea series.
在此，我们报告了强效且选择性的联芳基二酰胺衍生的MCH-R1受体拮抗剂1的发现，该拮抗剂是在对先前公开的联芳基脲系列进行修饰后确定的。本文描述了为去除存在于原本很有前景的联芳基脲系列中的高致突变性联芳基苯胺而采用的策略之一。
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