聚（甲基丙烯酸甲氧基六（乙二醇）酯）-b-（甲基丙烯酸2-（二乙氨基）乙酯）嵌段共聚物胶束金属化后的转变

Transformations of poly(methoxy hexa(ethylene glycol) methacrylate)-b-(2-(diethylamino)ethyl methacrylate) block copolymer micelles upon metalation.

作者信息

Bronstein Lyudmila M, Vamvakaki Maria, Kostylev Maxim, Katsamanis Vasilios, Stein Barry, Anastasiadis Spiros H

机构信息

Department of Chemistry and Department of Biology, Indiana University, Bloomington, IN 47405, USA.

出版信息

Langmuir. 2005 Oct 11;21(21):9747-55. doi: 10.1021/la0511337.

DOI:10.1021/la0511337

PMID:16207062

Abstract

Micelle transformations upon metalation (i.e., incorporation of metal compounds and metal nanoparticle formation) in poly(methoxy hexa(ethylene glycol) methacrylate)-block-poly((2-(diethylamino)ethyl methacrylate)), PHEGMA-b-PDEAEMA, solutions have been studied using transmission electron microscopy (TEM) and photon correlation spectroscopy (PCS). Three different methods for the formation of metalated micelles are compared: (A) dissolution of the block copolymers in pure water followed by incorporation of platinic acid (H(2)PtCl(6).6H(2)O), (B) micellization in acidic molecular solutions of block copolymers induced by interaction of the protonated amino groups with the PtCl(6)(2)(-) ions, and (C) incorporation of metal species in pH-induced micelles. The latter method leads to well-defined metalated micelles of 22-25 nm diameter containing nanoparticles with diameters of 1.3-1.5 nm. No nanoparticle aggregation is observed. Good agreement is obtained for the sizes of the platinic acid-containing micelles assessed by TEM and PCS.

摘要

利用透射电子显微镜（TEM）和光子相关光谱法（PCS）研究了聚（甲基丙烯酸六（乙二醇）甲酯）-嵌段-聚（甲基丙烯酸2-（二乙氨基）乙酯）（PHEGMA-b-PDEAEMA）溶液在金属化（即金属化合物的掺入和金属纳米颗粒的形成）过程中的胶束转变。比较了三种不同的形成金属化胶束的方法：（A）将嵌段共聚物溶解在纯水中，然后加入氯铂酸（H₂PtCl₆·6H₂O）；（B）由质子化氨基与PtCl₆²⁻离子相互作用诱导在嵌段共聚物的酸性分子溶液中进行胶束化；（C）在pH诱导的胶束中掺入金属物种。后一种方法产生直径为22 - 25 nm的明确金属化胶束，其中包含直径为1.3 - 1.5 nm的纳米颗粒。未观察到纳米颗粒聚集。通过TEM和PCS评估的含氯铂酸胶束的尺寸获得了良好的一致性。