Roszek Katarzyna, Gniot-Szulzycka Jadwiga
Department of Biochemistry, Institute of General and Molecular Biology, Nicolaus Copernicus University, 7 Gagarin St., 87-100 Torun, Poland.
Postepy Biochem. 2005;51(1):88-94.
The structure of several lysosomal membrane glycoproteins (lamp1, lamp2, limpI and limpII) has been described. The significance of the receptor glycoprotein lamp2a in the chaperone-mediated autophagy of cytosolic proteins with KFERQ motif has been described in details as well as the chaperone protein Hsc73 and other chaperones involved in this process. Several modulatory mechanisms of the chaperone-mediated autophagy, which is activated in condition of stress and starvation, were also outlined.
几种溶酶体膜糖蛋白（lamp1、lamp2、limpI和limpII）的结构已被描述。受体糖蛋白lamp2a在具有KFERQ基序的胞质蛋白伴侣介导的自噬中的意义以及伴侣蛋白Hsc73和参与此过程的其他伴侣蛋白也已详细描述。还概述了在应激和饥饿条件下被激活的伴侣介导的自噬的几种调节机制。
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