Chen C J, Shue C H
Department of Physiology, National Yang-Ming Medical College, Taipei, Taiwan, ROC.
Respiration. 1992;59(2):107-11. doi: 10.1159/000196037.
In order to understand how histamine-sensitized airways may react to exogenous dopamine, we investigated the effect of histamine treatment on the dopamine-induced contractions of canine tracheal smooth muscle. The results showed that preconstricting muscle strips with histamine (10(-6) M to 10(-4) M) not only increased the amplitude of dopamine-induced contraction, but also lowered the concentration of dopamine required to provoke contraction from 10(-4) M to 10(-6) M. In muscle strips desensitized by repeated challenges of 10(-3) M dopamine, a 15-min treatment with 10(-4) M histamine transiently restored the response. The restored contractions were decreased by the dopaminergic antagonist, domperidone, and the alpha 2-adrenoceptor antagonist, yohimbine, and increased by the beta 1-adrenoceptor antagonist, atenolol. It is concluded that in addition to its role in mediating airway constriction, histamine can promote and enhance the contractile response of canine tracheal smooth muscle to dopamine. Histamine treatment restored the dopamine response of desensitized tracheal muscle with resensitization of the adrenoceptors.
为了了解组胺致敏的气道对外源性多巴胺可能会如何反应，我们研究了组胺处理对犬气管平滑肌多巴胺诱导收缩的影响。结果显示，用组胺（10⁻⁶ M至10⁻⁴ M）预收缩肌条不仅增加了多巴胺诱导收缩的幅度，还将引发收缩所需的多巴胺浓度从10⁻⁴ M降至10⁻⁶ M。在经10⁻³ M多巴胺反复刺激而脱敏的肌条中，用10⁻⁴ M组胺处理15分钟可短暂恢复反应。恢复的收缩反应被多巴胺能拮抗剂多潘立酮和α₂肾上腺素能拮抗剂育亨宾降低，被β₁肾上腺素能拮抗剂阿替洛尔增加。得出的结论是，组胺除了在介导气道收缩中起作用外，还能促进和增强犬气管平滑肌对多巴胺的收缩反应。组胺处理通过肾上腺素能受体的再敏化恢复了脱敏气管肌对多巴胺的反应。
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