Wang Shengdian, Chen Lieping
The Sidney Kimmel Comprehensive Cancer Center, Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Cell Mol Immunol. 2004 Feb;1(1):37-42.
The past years have witnessed significant advance in our understanding of critical roles of T cell co-signals in B7-CD28 family molecules in regulating T cell activation and tolerance. New co-signaling molecules have been identified and their functions have been delineated. These co-signaling pathways play overlapping and distinct regulatory roles at various stages of a T cell response. By expressing in appropriate time and location, these pathways have different regulatory functions through independent receptors or on different subsets of lymphocytes. Precise understanding of these pathways will allow the development of novel approaches to treatment of human diseases such as cancer, viral infection, autoimmune diseases and transplantation rejection.
在过去几年里，我们对T细胞共信号分子在B7 - CD28家族分子中调节T细胞活化和耐受的关键作用的理解取得了重大进展。新的共信号分子已被鉴定出来，其功能也已明确。这些共信号通路在T细胞反应的各个阶段发挥着重叠且独特的调节作用。通过在适当的时间和位置表达，这些通路通过独立的受体或在淋巴细胞的不同亚群上具有不同的调节功能。对这些通路的精确理解将有助于开发治疗人类疾病的新方法，如癌症、病毒感染、自身免疫性疾病和移植排斥反应。
