Bruns Heather A, Kaplan Mark H
Department of Biology, Ball State University, 2000 West University Avenue CL 121, Muncie, IN 47306, USA.
Crit Rev Oncol Hematol. 2006 Mar;57(3):245-53. doi: 10.1016/j.critrevonc.2005.08.005. Epub 2005 Oct 5.
Signal transducers and activators of transcription (STAT) are a family of transcription factors that regulate a broad range of cellular processes, such as proliferation, differentiation, and survival, in a large variety of cell types. Because of their regulation of diverse cellular functions, their aberrant activation is frequently associated with disease development, particularly oncogenic diseases. Much evidence exists to suggest that STAT proteins play a significant role in cellular transformation. However, which STAT proteins and to what extent they cause transformation and subsequent disease progression are topics currently being investigated. In this review, we will report on the findings concerning the involvement of Stat6 in the development of lymphoma and leukemia. Mounting evidence, in both patients and mouse models, supports a model where Stat6 is not a mere bystander, but rather, plays an active role in promoting a transformed phenotype.
信号转导子和转录激活子（STAT）是一类转录因子家族，可调节多种细胞类型中的广泛细胞过程，如增殖、分化和存活。由于它们对多种细胞功能的调节作用，其异常激活常与疾病发展相关，尤其是致癌性疾病。有大量证据表明STAT蛋白在细胞转化中起重要作用。然而，哪些STAT蛋白以及它们在多大程度上导致转化和随后的疾病进展是目前正在研究的课题。在本综述中，我们将报告关于Stat6参与淋巴瘤和白血病发展的研究结果。在患者和小鼠模型中，越来越多的证据支持这样一种模型，即Stat6并非仅仅是旁观者，而是在促进转化表型方面发挥积极作用。
