Garcia-Diaz Miguel, Bebenek Katarzyna, Gao Guanghua, Pedersen Lars C, London Robert E, Kunkel Thomas A
Laboratory of Structural Biology and Laboratory of Molecular Genetics NIEHS, NIH, DHHS, Research Triangle Park, NC 27709, USA.
DNA Repair (Amst). 2005 Dec 8;4(12):1358-67. doi: 10.1016/j.dnarep.2005.09.001. Epub 2005 Oct 4.
DNA polymerase lambda is a member of the X family of polymerases that is implicated in non-homologous end-joining of double-strand breaks in DNA and in base excision repair of DNA damage. To better understand the roles of DNA polymerase lambda in these repair pathways, here we review its structure and biochemical properties, with emphasis on its gap-filling polymerization activity, its dRP lyase activity and its unusual DNA synthetic (in)fidelity.
DNA聚合酶λ是聚合酶X家族的成员，参与DNA双链断裂的非同源末端连接以及DNA损伤的碱基切除修复。为了更好地理解DNA聚合酶λ在这些修复途径中的作用，我们在此综述其结构和生化特性，重点关注其填补缺口的聚合活性、dRP裂解酶活性以及其异常的DNA合成保真度。
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