Martínez-Raga José, Didia-Attas Javier, Ruiz Martín, Knecht Carlos C, Cepeda Sonsoles, San Molina Luis, Pérez-Gálvez Bartolome
Instituto de Drogas y Conductas Adictivas, Universidad Cardenal Herrera, CEU y Agencia Valenciana de Salud, España.
Vertex. 2005 Sep-Oct;16(63):325-31.
Post-traumatic stress disorder (PTSD) is frequently associated with other psychiatric diagnoses, being substance use disorder (SUD) one of the most prevailing. Comorbid disorders in general and SUD in particular frequently complicate the course and outcome of PTSD, and vice versa. As with other dual disorders, comorbidity of PTSD and SUD is complex, having been proposed different theoretical models to explain it that will be discussed in the present paper, the first of a series of two. In addition, the present paper reviews data from epidemiological studies, as well as the clinical characteristics, the relevance of stressful life events as a vulnerability factor to PTSD as well as to SUD and the neurobiological basis of the association of both disorders with the aim of gaining a better understanding of this comorbidity, so that the treatment of this dual disorder will be discussed in the second part.
创伤后应激障碍（PTSD）常与其他精神疾病诊断相关联，物质使用障碍（SUD）是最常见的一种。一般来说，共病障碍尤其是SUD常常使PTSD的病程和结局复杂化，反之亦然。与其他双重障碍一样，PTSD和SUD的共病情况很复杂，本文提出了不同的理论模型来解释这一现象，本文是系列两篇文章中的第一篇。此外，本文回顾了流行病学研究数据，以及临床特征、应激性生活事件作为PTSD和SUD易感性因素的相关性，以及这两种障碍关联的神经生物学基础，旨在更好地理解这种共病情况，以便在第二部分讨论这种双重障碍的治疗。
