[肉豆蔻酸异丙酯分子凝胶及载药透皮能力]

[Isopropyl myristate molecular gels and drug-loaded transdermal capability].

作者信息

Lin Li-hua, Zhang Xue-qin, Yang Ya-jiang, Yang Xiang-liang, Xu Hui-bi

机构信息

Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China.

出版信息

Yao Xue Xue Bao. 2005 May;40(5):470-4.

PMID:16220796

Abstract

AIM

To prepare of isopropyl myristate (IPM) molecular gels and investigate of its transdermal capability.

METHODS

Microstructure of IPM gels was studied by scanning electron microscope (SEM) and optical microscope (OM). The rheology and thixotropy of IPM gels were investigated by viscosity. Triptolide was used as model drug to investigate its transdermal capability.

RESULTS

The microstructure of IPM gels was a three-dimension network formed by the aggregation of Span 60 in IPM, which was rod-like tubular aggregate. It has good rheology and thixotropy. There was a good linear correlation between the accumulative permeated amount per unit area and the time for triptolide-loaded IPM gels. The permeation process agreed with zero order pharmacokinetics. The average permeability through rat skin for triptolide was 19.26 ng x cm(-2) x h(-1), which was 2.92 times of triptolide unguents obtained commercially available.

CONCLUSION

Isopropyl myristate molercular gel can be formed by span 60 assemblies. Transdermal capability drug-loaded IPM gels was better than that of triptolide unguents.

摘要

目的

制备肉豆蔻酸异丙酯（IPM）分子凝胶并研究其透皮性能。

方法

通过扫描电子显微镜（SEM）和光学显微镜（OM）研究IPM凝胶的微观结构。通过粘度研究IPM凝胶的流变学和触变性。以雷公藤甲素为模型药物研究其透皮性能。

结果

IPM凝胶的微观结构是由IPM中Span 60聚集形成的三维网络，为棒状管状聚集体。它具有良好的流变学和触变性。载雷公藤甲素的IPM凝胶单位面积累积渗透量与时间之间存在良好的线性相关性。渗透过程符合零级药代动力学。雷公藤甲素对大鼠皮肤的平均渗透率为19.26 ng·cm⁻²·h⁻¹，是市售雷公藤甲素软膏的2.92倍。