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带支架腹主动脉瘤模型中Ⅱ型内漏的计算分析

Computational analysis of type II endoleaks in a stented abdominal aortic aneurysm model.

作者信息

Li Z, Kleinstreuer C

机构信息

Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910, USA.

出版信息

J Biomech. 2006;39(14):2573-82. doi: 10.1016/j.jbiomech.2005.09.002. Epub 2005 Oct 10.

Abstract

Insertion of a stent-graft into an aneurysm to form a new (synthetic) blood vessel and prevent the weakened artery wall from rupture is an attractive surgical intervention when compared to traditional open surgery. However, focusing on a stented abdominal aortic aneurysm (AAA), post-operative complications such as endoleaks may occur. An endoleak is the net influx of blood during the cardiac cycle into the cavity (or sac) formed by the stent-graft and the AAA wall. A natural endoleak source may stem from one or two secondary branches leading to and from the aneurysm, labeled types IIa and IIb endoleaks. Employing experimentally validated fluid-structure interaction solvers, the transient 3-D lumen and cavity blood flows, wall movements, pressure variations, maximum wall stresses and migration forces were computed for types IIa and IIb endoleaks. Simulation results indicate that the sac pressure caused by these endoleaks depends largely on the inlet branch pressure, where the branch inlet pressure increases, the sac pressure may reach the systemic level and AAA-rupture is possible. The maximum wall stress is typically located near the anterior-distal side in this model, while the maximum stent-graft stress occurs near the bifurcating point, in both cases, due to local stress concentrations. The time-varying leakage rate depends on the pressure difference between AAA sac and inlet branch. In contrast, the stent-graft migration force is reduced by type II endoleaks because it greatly depends on the pressure difference between the stent-graft and the aneurysm cavity.

摘要

与传统的开放手术相比,将支架型人工血管植入动脉瘤以形成新的(合成)血管并防止薄弱的动脉壁破裂是一种有吸引力的外科干预措施。然而,对于置入支架的腹主动脉瘤(AAA),术后可能会出现诸如内漏等并发症。内漏是指在心动周期中血液净流入由支架型人工血管和AAA壁形成的腔(或囊)内。自然内漏源可能源于通向和来自动脉瘤的一两个二级分支,分别称为IIa型和IIb型内漏。利用经过实验验证的流固耦合求解器,计算了IIa型和IIb型内漏的瞬态三维管腔和腔内血流、壁运动、压力变化、最大壁应力和迁移力。模拟结果表明,这些内漏引起的囊内压力在很大程度上取决于分支入口压力,随着分支入口压力升高,囊内压力可能达到体循环水平,AAA有破裂的可能。在该模型中,最大壁应力通常位于前远端附近,而最大支架型人工血管应力出现在分叉点附近,这两种情况都是由于局部应力集中所致。随时间变化的漏血率取决于AAA囊和分支入口之间的压力差。相比之下,II型内漏会降低支架型人工血管的迁移力,因为它在很大程度上取决于支架型人工血管和动脉瘤腔之间的压力差。

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