Behrens Christoph J, van den Boom Leander P, de Hoz Livia, Friedman Alon, Heinemann Uwe
Institute for Neurophysiology, Charité-Universitätsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany.
Nat Neurosci. 2005 Nov;8(11):1560-7. doi: 10.1038/nn1571. Epub 2005 Oct 16.
Hippocampal sharp wave-ripple complexes (SPW-Rs) occur during slow-wave sleep and behavioral immobility and are thought to represent stored information that is transferred to the neocortex during memory consolidation. Here we show that stimuli that induce long-term potentiation (LTP), a neurophysiological correlate of learning and memory, can lead to the generation of SPW-Rs in rat hippocampal slices. The induced SPW-Rs have properties that are identical to spontaneously generated SPW-Rs: they originate in CA3, propagate to CA1 and subiculum and require AMPA/kainate receptors. Their induction is dependent on NMDA receptors and involves changes in interactions between clusters of neurons in the CA3 network. Their expression is blocked by low-frequency stimulation but not by NMDA receptor antagonists. These data indicate that induction of LTP in the recurrent CA3 network may facilitate the generation of SPW-Rs.
海马体尖波-涟漪复合体（SPW-Rs）出现在慢波睡眠和行为静止期间，被认为代表了在记忆巩固过程中转移到新皮层的存储信息。在这里，我们表明，诱导长时程增强（LTP）（学习和记忆的一种神经生理相关物）的刺激可导致大鼠海马体切片中产生SPW-Rs。诱导产生的SPW-Rs具有与自发产生的SPW-Rs相同的特性：它们起源于CA3区，传播至CA1区和海马下托，并且需要AMPA/海人酸受体。它们的诱导依赖于NMDA受体，并且涉及CA3网络中神经元簇之间相互作用的变化。它们的表达可被低频刺激阻断，但不能被NMDA受体拮抗剂阻断。这些数据表明，在CA3循环网络中诱导LTP可能会促进SPW-Rs的产生。
