神经性大鼠冷觉异常对酚妥拉明敏感性的个体差异。
Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.
作者信息
Kim Sun Kwang, Min Byung-Il, Kim Ji Hoon, Hwang Byung Gil, Yoo Gi Yong, Park Dong Suk, Na Heung Sik
机构信息
Department of East-West Medicine, Graduate School, Kyung-Hee University, Seoul, South Korea.
出版信息
Eur J Pharmacol. 2005 Oct 31;523(1-3):64-6. doi: 10.1016/j.ejphar.2005.08.030. Epub 2005 Oct 14.
In neuropathic rats sensitive to phentolamine (alpha-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (alpha1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the alpha-adrenoreceptor subtype predominantly involved in cold allodynia.
在对酚妥拉明（α-肾上腺素能受体拮抗剂，2毫克/千克，腹腔注射）敏感的神经病变大鼠中，哌唑嗪（α1-肾上腺素能受体拮抗剂，0.5毫克/千克，腹腔注射）显著减轻了冷痛觉过敏，而育亨宾（α2-肾上腺素能受体拮抗剂，0.5毫克/千克，腹腔注射）则没有显著影响。在对酚妥拉明不敏感的神经病变大鼠中，育亨宾显著加剧了冷痛觉过敏，而哌唑嗪则没有显著影响。这些结果表明，冷痛觉过敏对酚妥拉明敏感性的个体差异可能是由于主要参与冷痛觉过敏的α-肾上腺素能受体亚型的差异所致。
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