使用无铝疫苗进行低剂量皮内甲型肝炎疫苗接种具有免疫原性且可降低成本。

Reduced-dose intradermal vaccination against hepatitis A with an aluminum-free vaccine is immunogenic and can lower costs.

作者信息

Pancharoen Chitsanu, Mekmullica Jutarat, Thisyakorn Usa, Kasempimolporn Songsri, Wilde Henry, Herzog Christian

机构信息

Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

出版信息

Clin Infect Dis. 2005 Nov 15;41(10):1537-40. doi: 10.1086/497266. Epub 2005 Oct 13.

DOI:10.1086/497266

PMID:16231271

Abstract

A reduced dose (0.1 mL) of intradermal hepatitis A virus (HAV) vaccine could facilitate the control of hepatitis A in countries of endemicity. All study subjects receiving an aluminum-free HAV vaccine intradermally were seroprotected 28 days after vaccination (anti-HAV titer, > or =10 mIU/mL). Seroprotection rates decreased to 80.8% at 12 months but returned to 100%, with titers increasing 28-fold, after receipt of a booster vaccination.

摘要

降低剂量（0.1毫升）的皮内甲型肝炎病毒（HAV）疫苗有助于在甲型肝炎流行国家控制该病。所有接受无铝HAV皮内疫苗接种的研究对象在接种后28天均获得血清保护（抗-HAV滴度≥10 mIU/mL）。12个月时血清保护率降至80.8%，但在接受加强免疫接种后恢复到100%，滴度增加了28倍。