Melero Ignacio, Arina Ainhoa, Chen Lieping
Department of Medicine, CIMA and Clinica Universitaria, University of Navarra, Pamplona, Spain.
Immunol Res. 2005;33(2):135-47. doi: 10.1385/IR:33:2:135.
It is not unusual for antigens and potentially responsive T cells to co-exist in the same organism while these T cells remain silent and do not mount life-threatening immune responses. A rich array of mechanisms has been proposed to explain these observations. T cell silencing is controlled in multiple levels. Initially, dendritic cells and regulatory T cells appear to play critical roles. In addition, T cell immunity is tightly regulated by a molecular network of cytokines and cell receptor interactions by the opposed surfaces of antigen-presenting cells and T cells. Recognition of a specific antigen is therefore shaped and tuned by co-stimulatory and co-inhibitory receptor-ligand pairs. At last, immunologists are beginning to exploit the rules governing these assorted sounds of T cell silence.
抗原和潜在反应性T细胞在同一生物体中共存，而这些T细胞保持沉默且不引发危及生命的免疫反应，这种情况并不罕见。人们提出了一系列丰富的机制来解释这些现象。T细胞沉默在多个层面受到控制。最初，树突状细胞和调节性T细胞似乎起着关键作用。此外，T细胞免疫受到细胞因子分子网络以及抗原呈递细胞和T细胞相对表面之间细胞受体相互作用的严格调控。因此，特定抗原的识别是由共刺激和共抑制受体-配体对塑造和调节的。最后，免疫学家们开始探索支配这些T细胞沉默各种情况的规则。
