Schatz Michael, Nakahiro Randy, Crawford William, Mendoza Guillermo, Mosen David, Stibolt Thomas B
Department of Allergy, Kaiser-Permanente Medical Center, San Diego, Los Angeles, CA 92111, USA.
Chest. 2005 Oct;128(4):1968-73. doi: 10.1378/chest.128.4.1968.
To evaluate the relationship of potential asthma quality-of-care markers to subsequent emergency hospital care.
Retrospective administrative database analysis.
Managed care organization.
Asthmatic patients aged 5 to 56 years of age.
None.
Candidate quality measures included one or more or four or more controller medication canisters, a controller/total asthma medication ratio of > or = 0.3 or > or = 0.5, and the dispensing of fewer than six beta-agonist canisters in 2002. Outcome was a 2003 asthma emergency department visit or hospitalization. Multivariable analyses adjusted for age, sex, and year 2002 severity (based on utilization). In the total sample (n = 109,774), one or more controllers (odds ratio, 1.35) and four or more controllers (odds ratio, 1.98) were associated with an increased risk of emergency hospital care, whereas a controller/total asthma medication ratio of > or = 0.5 (odds ratio, 0.73) and the dispensing of fewer than six beta-agonist canisters (odds ratio 0.30) were associated with a decreased risk. After adjustment for baseline severity in the total asthma sample, the controller/total asthma medication ratio (odds ratio, 0.62 to 0.78) and beta-agonist measure (odds ratio, 0.42) were associated with decreased risk, whereas the dispensing of four or more canisters of controller medication was associated with increased risk (odds ratio, 1.33). After stratification by year 2002 beta-agonist use, all of the measures were associated with decreased risk in those who received fewer than six beta-agonist canisters, whereas all of the measures except the medication ratio of > or = 0.5 were associated with increased risk in the cohort who received six or more beta-agonist canisters.
Controller use and beta-agonist use may function as severity indicators in large populations rather than as asthma quality-of-care markers. A medication ratio of > or = 0.5 appeared to function as the best quality-of-care marker in this study.
评估潜在的哮喘医疗质量指标与随后的急诊医院治疗之间的关系。
回顾性管理数据库分析。
管理式医疗组织。
年龄在5至56岁之间的哮喘患者。
无。
候选质量指标包括一个或多个或四个或更多控制药物吸入器、控制药物/总哮喘药物比例≥0.3或≥0.5,以及2002年β-激动剂吸入器配药量少于六个。结果是2003年哮喘急诊就诊或住院。多变量分析对年龄、性别和2002年严重程度(基于利用率)进行了调整。在总样本(n = 109,774)中,一个或多个控制药物(比值比,1.35)和四个或更多控制药物(比值比,1.98)与急诊医院治疗风险增加相关,而控制药物/总哮喘药物比例≥0.5(比值比,0.73)和β-激动剂吸入器配药量少于六个(比值比0.30)与风险降低相关。在对总哮喘样本的基线严重程度进行调整后,控制药物/总哮喘药物比例(比值比,0.62至0.78)和β-激动剂指标(比值比,0.42)与风险降低相关,而四个或更多控制药物吸入器的配药与风险增加相关(比值比,1.33)。按2002年β-激动剂使用情况分层后,所有指标在接受少于六个β-激动剂吸入器的患者中与风险降低相关,而在接受六个或更多β-激动剂吸入器的队列中,除了≥0.5的药物比例外,所有指标与风险增加相关。
在大量人群中,控制药物的使用和β-激动剂的使用可能作为严重程度指标,而非哮喘医疗质量指标。在本研究中,≥0.5的药物比例似乎是最佳的医疗质量指标。