Sunada Fumiko, Itabashi Masayuki, Ohkura Hisanao, Okumura Toshiyuki
Department of Internal Medicine, Jichi Medical School Hospital, Yakushiji 3311, Minamikawachi-machi, Kawachi-gun, Japan.
World J Gastroenterol. 2005 Sep 28;11(36):5696-700. doi: 10.3748/wjg.v11.i36.5696.
Esophageal squamous cell carcinoma is generally sensitive to chemoradiotherapy (CRT), but some cases are not. Using a retrospective analysis, we aimed to identify the predictors of the response by esophageal squamous cell carcinoma to definitive CRT.
The intensities of expression of p53, Ki67, Bcl-2, Bax, cyclin D1, VEGF, CDC25B, and metallothionein (MT) were evaluated immunohistochemically in the biopsy specimens obtained before CRT, and the intensities of their expression were tested for correlations with the clinical effects of CRT.
The esophageal squamous cell carcinomas with negative p53, positive CDC25B, and negative MT expression were found to be significantly more sensitive to CRT. In addition, p53 positivity and CDC25B positivity respond well to CRT.
Esophageal squamous cell carcinomas with negative p53, positive CDC25B, and negative MT expressions respond well to CRT. Even with p53 positivity, if with CDC25B positivity, CRT can be expected.
食管鳞状细胞癌通常对放化疗(CRT)敏感,但部分病例并非如此。通过回顾性分析,我们旨在确定食管鳞状细胞癌对根治性CRT反应的预测因素。
在CRT前获取的活检标本中,采用免疫组织化学方法评估p53、Ki67、Bcl-2、Bax、细胞周期蛋白D1、血管内皮生长因子(VEGF)、细胞周期蛋白依赖性激酶25B(CDC25B)和金属硫蛋白(MT)的表达强度,并检测其表达强度与CRT临床疗效的相关性。
发现p53阴性、CDC25B阳性和MT表达阴性的食管鳞状细胞癌对CRT明显更敏感。此外,p53阳性和CDC25B阳性对CRT反应良好。
p53阴性、CDC25B阳性和MT表达阴性的食管鳞状细胞癌对CRT反应良好。即使p53阳性,但如果伴有CDC25B阳性,也可预期CRT有效。