Jaffe William I, Te Alexis E
Temple University School of Medicine, Broad and Ontario Streets, Suite 350 Parkinson Pavilion, Philadelphia, PA 19140, USA.
Curr Urol Rep. 2005 Nov;6(6):410-8. doi: 10.1007/s11934-005-0034-1.
The urologist's approach to the diagnosis and treatment of lower urinary tract symptoms (LUTS) in male patients has changed significantly over the past decade. Advances in the basic science arena combined with a wealth of clinical data have pointed to the importance of bladder pathophysiology in the development of urinary symptoms. Historically, men with LUTS were diagnosed with "prostatism," an all-encompassing term that includes both voiding and storage symptoms that may or may not be related to prostatic obstruction. Parallel to the scientific advances in the field, the urologic lexicon began to evolve and has allowed us to more specifically describe, and therefore investigate and treat, different aspects of male LUTS. It is now well recognized that many men suffer from storage symptoms that may be more related to bladder dysfunction than to prostatic obstruction. It will be critical to integrate our knowledge of prostatic growth and obstruction, the bladder response to outlet obstruction, environmental and lifestyle factors, and age-related changes to fully understand the complex pathophysiology of male LUTS, specifically overactive bladder syndrome.
在过去十年中,泌尿科医生对男性患者下尿路症状(LUTS)的诊断和治疗方法发生了显著变化。基础科学领域的进展与丰富的临床数据表明,膀胱病理生理学在泌尿系统症状的发生发展中具有重要意义。从历史上看,患有LUTS的男性被诊断为“前列腺增生症”,这是一个涵盖排尿和储尿症状的综合性术语,这些症状可能与前列腺梗阻有关,也可能无关。随着该领域科学的进步,泌尿外科术语开始演变,使我们能够更具体地描述,进而研究和治疗男性LUTS的不同方面。现在人们已经充分认识到,许多男性存在储尿症状,这些症状可能与膀胱功能障碍的关系比与前列腺梗阻的关系更大。整合我们对前列腺生长和梗阻、膀胱对出口梗阻的反应、环境和生活方式因素以及与年龄相关变化的认识,对于全面理解男性LUTS的复杂病理生理学,尤其是膀胱过度活动症至关重要。