口服氧化洛哌丁胺后洛哌丁胺的剂量比例研究。
Dose proportionality study of loperamide following oral administration of loperamide oxide.
作者信息
Kamali F, Adriaens L, Huang M L, Woestenborghs R, Emanuel M, Rawlins M D
机构信息
Wolfson Unit of Clinical Pharamcology, The University, Newcastle upon Tyne, UK.
出版信息
Eur J Clin Pharmacol. 1992;42(6):693-4. doi: 10.1007/BF00265940.
PMID:1623916
Abstract
The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.
摘要
采用随机交叉设计，在10名健康男性志愿者中研究了口服递增剂量（1至16毫克）氧化洛哌丁胺后洛哌丁胺的药代动力学。最大血浆洛哌丁胺浓度和AUC的比较表明，洛哌丁胺的生物利用度与所给药的氧化洛哌丁胺剂量成正比。
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