Charloux Anne, Chaouat Ari, Brandenberger Gabrielle, Piquard François, Weitzenblum Emmanuel, Geny Bernard
Laboratoire des Régulations Physiologiques et des Rythmes Biologiques chez l'Homme, Institut de Physiologie, 4 rue Kirschleger, 67085 Strasbourg Cedex, France.
Peptides. 2006 Apr;27(4):864-70. doi: 10.1016/j.peptides.2005.09.005. Epub 2005 Oct 19.
A pulsatile secretory pattern is assumed to improve hormonal efficiency. We examined the short-term time courses of circulating atrial (ANP) and brain natriuretic peptides (BNP) in patients with pulmonary hypertension (PH) and reduced renal efficiency of ANP-BNP, reflected by low natriuresis/ANP or BNP ratios. Compared to controls, we observed a persistence of ANP and BNP pulsatility in PH patients with a similar periodicity of 20min. Pulse amplitude increased proportionally to the rise in mean plasma level observed in patients (around 27%). In PH patients, the decrease in ANP-BNP renal efficiency is not attributable to a loss of the rhythmic pulsatility of these hormones.
