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Arsenic Trioxide inhibits the growth of human ovarian carcinoma cell line.

作者信息

Bornstein Jacob, Sagi Shlomi, Haj Amer, Harroch Jeffrey, Fares Fuad

机构信息

Department of Obstetrics and Gynecology, Western Galilee Hospital, PO Box 21, Nahariya 22100, and Molecular Genetics Laboratory, Technion-Israel Institute of Technology, Haifa, Israel.

出版信息

Gynecol Oncol. 2005 Dec;99(3):726-9. doi: 10.1016/j.ygyno.2005.07.125. Epub 2005 Oct 21.

Abstract

OBJECTIVE

To determine whether Arsenic Trioxide may be an effective treatment of human ovarian carcinoma, we examined if it induced apoptosis in human ovarian cancer cell line.

METHODS

The human ovarian cell line SKOV3 was exposed to different concentrations of As2O3: 0 (control), 0.1 microM, 1 microM, 5 microM and 10 microM. The effect on cells proliferation and apoptotic parameters was examined.

RESULTS

The most effective inhibitory Arsenic Trioxide concentrations were 5 microM and 10 microM, causing growth inhibition of 79% and 83%, respectively. The maximum inhibitory effect of Arsenic Trioxide on cellular proliferation was seen after 48 h. No morphological or molecular features of apoptosis have been observed. At the same time, there were no typical changes of cellular necrosis.

CONCLUSIONS

The exact mechanism by which Arsenic Trioxide inhibits the growth of ovarian cancer cells is probably not by apoptosis. However, since As2O3 has been shown to inhibit ovarian cancer cellular growth, it should be further elucidated as a possible chemotherapeutic agent of ovarian cancer.

摘要

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