体内质子磁共振波谱分析的唾液腺肿瘤

Salivary gland tumors at in vivo proton MR spectroscopy.

作者信息

King Ann D, Yeung David K W, Ahuja Anil T, Tse Gary M K, Yuen H Y, Wong K T, van Hasselt Andrew C

机构信息

Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

出版信息

Radiology. 2005 Nov;237(2):563-9. doi: 10.1148/radiol.2372041309.

DOI:10.1148/radiol.2372041309

PMID:16244265

Abstract

PURPOSE

To prospectively evaluate whether proton magnetic resonance (MR) spectroscopy can be used to characterize salivary gland tumors (SGTs).

MATERIALS AND METHODS

Ethics committee approval and informed consent were obtained. Hydrogen 1 ((1)H) MR spectroscopy was performed with echo times of 136 and 272 msec at 1.5 T in both SGTs and normal parotid glands. Spectra were analyzed in the time domain by using prior knowledge in the fitting procedure to obtain peak amplitudes of choline (Cho), creatine (Cr), and unsuppressed water. Mean Cho/Cr and Cho/water ratios for each subgroup of SGTs were obtained, and results were compared by using a nonparametric t test.

RESULTS

Successful spectra were acquired in 56 patients (35 men, 21 women; mean age, 56 years) with a total of nine malignant tumors and 47 benign SGTs (24 Warthin tumors, 22 pleomorphic adenomas, one oncocytoma). At an echo time of 136 msec, Cho/Cr ratios were obtained in 26 (47%) of 55 spectra, with a mean value (+/- standard deviation) of 1.73 +/- 0.47, 5.49 +/- 1.86, 3.46 +/- 0.84, and 2.45 for malignant tumors, Warthin tumors, pleomorphic adenomas, and oncocytoma, respectively. Differences were significant between Warthin tumors and pleomorphic adenomas (P = .028) and between benign SGTs and malignant tumors (P < .001). At an echo time of 272 msec, Cho/Cr ratios were obtained in 16 (30%) of 53 spectra, with a mean value of 2.27 +/- 0.69, 6.92 +/- 1.47, and 3.67 +/- 1.23 for malignant tumors, Warthin tumors, and pleomorphic adenomas, respectively. Differences were also significant between Warthin tumors and pleomorphic adenomas (P = .041) and benign SGTs and malignant tumors (P = .004). There was a significant difference in mean Cho/water ratio for Warthin tumors versus pleomorphic adenomas at echo times of 136 msec (P = .003) and 272 msec (P = .002) but not for benign SGTs versus malignant tumors.

CONCLUSION

(1)H MR spectroscopy may be used to characterize SGTs, but a larger study is required to validate these initial results.

摘要

目的

前瞻性评估质子磁共振（MR）波谱是否可用于鉴别涎腺肿瘤（SGT）。

材料与方法

获得伦理委员会批准并取得知情同意。在1.5T场强下，对SGT和正常腮腺进行回波时间分别为136和272毫秒的氢1（（1）H）MR波谱分析。在拟合过程中利用先验知识在时域分析波谱，以获取胆碱（Cho）、肌酸（Cr）和未抑制水的峰高。获取各SGT亚组的平均Cho/Cr和Cho/水比值，并采用非参数t检验比较结果。

结果

共56例患者（35例男性，21例女性；平均年龄56岁）成功采集波谱，其中恶性肿瘤9例，良性SGT 47例（24例沃辛瘤，22例多形性腺瘤，1例嗜酸细胞瘤）。在回波时间为136毫秒时，55个波谱中的26个（47%）获得了Cho/Cr比值，恶性肿瘤、沃辛瘤、多形性腺瘤和嗜酸细胞瘤的平均值（±标准差）分别为1.73±0.47、5.49±1.86、3.46±0.84和2.45。沃辛瘤与多形性腺瘤之间（P = 0.028）以及良性SGT与恶性肿瘤之间（P < 0.001）差异有统计学意义。在回波时间为272毫秒时，53个波谱中的16个（30%）获得了Cho/Cr比值，恶性肿瘤、沃辛瘤和多形性腺瘤的平均值分别为2.27±0.69、6.92±1.47和3.67±1.23。沃辛瘤与多形性腺瘤之间（P = 0.041）以及良性SGT与恶性肿瘤之间（P = 0.004）差异也有统计学意义。在回波时间为136毫秒（P = 0.003）和272毫秒（P = 0.002）时，沃辛瘤与多形性腺瘤的平均Cho/水比值有显著差异，但良性SGT与恶性肿瘤之间无显著差异。