Høiseth Gudrun, Hjelmeland Knut, Bachs Liliana
Divisjon for rettstoksikologi og rusmiddelforskning, Nasjonalt folkehelseinstitutt, Postboks 4404 Nydalen, 0403 Oslo.
Tidsskr Nor Laegeforen. 2005 Oct 20;125(20):2775-6.
For the first time in ten years, phencyclidine (PCP) has been confiscated in Norway. Physicians should be aware of this substance when treating intoxications.
Relevant literature was identified by search in Medline. This review presents the pharmacological properties and effects of phencyclidine as well as symptoms and treatment of phencyclidine intoxication.
Phencyclidine exhibits hallucinogenic, depressant and stimulant properties. Phencyclidine interacts as an antagonist to the N-methyl-D-aspartate (NMDA) receptor in the central nervous system. Severe NMDA receptor hypofunction can elicit clinical symptoms similar to a schizophrenic episode.
挪威十年来首次查获苯环己哌啶（PCP）。医生在治疗中毒患者时应留意这种物质。
通过检索医学期刊数据库（Medline）来查找相关文献。本综述介绍了苯环己哌啶的药理特性和作用，以及苯环己哌啶中毒的症状与治疗方法。
苯环己哌啶具有致幻、抑制和兴奋特性。它在中枢神经系统中作为N-甲基-D-天冬氨酸（NMDA）受体的拮抗剂发挥作用。严重的NMDA受体功能减退可引发类似于精神分裂症发作的临床症状。
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