Gong Xia, Le Guo-Wei, Li Yun-Fei
Department of Food Science and Engineering, Shanghai Jiaotong University, Shanghai 200030, China.
Wei Sheng Wu Xue Bao. 2005 Aug;45(4):516-20.
In vitro antibacterial activities of three antibacterial peptides, alone and in combination with the antibiotics were measured by MIC and antibacterial spectrum. Synergy was observed when the peptides were combined with penicillin, streptomycin by FIC. The results show that antibacterial peptides have stronger inhibition of pathogenic bacterium, and antibacterial spectrum are very different. The interaction in antibacterial peptides, antibiotics and bacterium is extraordinary complex, except synergic action, there are antagonism and indifference.
通过最小抑菌浓度(MIC)和抗菌谱测定了三种抗菌肽单独以及与抗生素联合使用时的体外抗菌活性。当抗菌肽与青霉素、链霉素联合使用时,根据分数抑菌浓度(FIC)观察到协同作用。结果表明,抗菌肽对病原菌具有更强的抑制作用,且抗菌谱差异很大。抗菌肽、抗生素和细菌之间的相互作用极其复杂,除了协同作用外,还存在拮抗作用和无相互作用的情况。