POU结构域转录因子Oct-6在精神分裂症、双相情感障碍和重度抑郁症中的表达
Expression of POU-domain transcription factor, Oct-6, in schizophrenia, bipolar disorder and major depression.
作者信息
Ubhi Kirenjeet, Price Jack
机构信息
Institute of Psychiatry, Kings College London, Denmark Hill, London, UK.
出版信息
BMC Psychiatry. 2005 Oct 24;5:38. doi: 10.1186/1471-244X-5-38.
BACKGROUND
The POU-domain transcription factor Oct-6 has been reported to be differentially expressed between schizophrenic and control post-mortem brains. In this study, we attempted to replicate this finding and to discover whether Oct-6 was also dysregulated in bipolar disorder and major depression.
METHODS
Oct-6 mRNA and protein expression were determined by in-situ hybridization and immunohistochemistry respectively in sections of post-mortem brain.
RESULTS
We did not observe any differences in Oct-6 expression between any of the groups under study. Oct-6 mRNA and protein was identically expressed in the hippocampal and cortical regions of most specimens in all groups, including controls.
CONCLUSION
Oct-6 is, therefore, unlikely to be a specific marker for any psychological disorder; rather its expression in controls suggests that it is normally expressed in most adult brains.
背景
据报道，POU结构域转录因子Oct-6在精神分裂症患者与对照者的死后大脑中存在差异表达。在本研究中，我们试图重复这一发现，并探究Oct-6在双相情感障碍和重度抑郁症中是否也存在表达失调。
方法
分别通过原位杂交和免疫组化法测定死后大脑切片中Oct-6的mRNA和蛋白表达。
结果
我们未观察到所研究的任何组之间Oct-6表达存在差异。Oct-6的mRNA和蛋白在所有组（包括对照组）大多数标本的海马体和皮质区域中表达相同。
结论
因此，Oct-6不太可能是任何心理障碍的特异性标志物；相反，它在对照组中的表达表明其在大多数成人大脑中正常表达。
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