Zhang Nu, Hartig Heather, Dzhagalov Ivan, Draper David, He You Wen
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Cell Res. 2005 Oct;15(10):749-69. doi: 10.1038/sj.cr.7290345.
Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family members and the extrinsic cell death pathway controlled by death receptor signaling. These two pathways work together to regulate T lymphocyte development and function.
细胞凋亡在T细胞生物学中起着至关重要的作用。在发育过程中，表达无功能或自身反应性TCR的胸腺细胞通过细胞凋亡被清除。细胞凋亡还会导致免疫反应期间扩增的效应T细胞的缺失。免疫系统中细胞凋亡的失调会导致自身免疫、肿瘤发生和免疫缺陷。两条主要途径导致细胞凋亡：由Bcl-2家族成员控制的内在细胞死亡途径和由死亡受体信号传导控制的外在细胞死亡途径。这两条途径共同作用以调节T淋巴细胞的发育和功能。
