Kurosaka Shinji, Irie Akira, Mizoguchi Hideyuki, Okuno Norihiko, Iwabuchi Keiichi, Baba Shiro
Department of Urology, Kitasato Institute Hospital, 5-9-1 Shirokane, Tokyo 108-8642, Japan.
Int J Clin Oncol. 2005 Oct;10(5):362-5. doi: 10.1007/s10147-005-0497-6.
A 52-year-old woman was referred to our institute for the evaluation of a tumor in her pelvic cavity. The tumor seemed to have arisen from the bladder or urethra, and bilateral iliac lymphadenopathy was seen. Her urethral mucosa looked intact according to the results of cystourethroscopy. Histopathological examination of the biopsy specimens showed clear-cell adenocarcinoma. She underwent radical cystourethrectomy with complete pelvic lymph node dissection and the construction of a bilateral ureterocutaneostomy. Macroscopically, the tumor had arisen from the trigone of the bladder, and histopathological examination of the tumor revealed adenocarcinoma exhibiting solid clear cells with glandular and papillary patterns. The tumor had infiltrated perivesical structure (pT3a), and metastases in multiple pelvic lymph nodes were recognized (pN3). Postoperatively, three courses of systemic combination chemotherapy with 5-fluouracil (FU) and cisplatin, along with a total of 45 Gy of irradiation during the second course of chemotherapy, were conducted. No evidence of the disease has been seen 28 months after the surgery.
一名52岁女性因盆腔肿物被转诊至我院。该肿物似乎起源于膀胱或尿道，且可见双侧髂淋巴结肿大。膀胱尿道镜检查结果显示其尿道黏膜完整。活检标本的组织病理学检查显示为透明细胞腺癌。她接受了根治性膀胱尿道切除术、盆腔淋巴结清扫术及双侧输尿管皮肤造口术。大体检查显示，肿瘤起源于膀胱三角区，肿瘤的组织病理学检查显示腺癌呈实性透明细胞，伴有腺管状和乳头状结构。肿瘤侵犯膀胱周围结构（pT3a），并在多个盆腔淋巴结发现转移（pN3）。术后，进行了三个疗程的5-氟尿嘧啶（FU）和顺铂全身联合化疗，在第二个化疗疗程期间共进行了45 Gy的放疗。术后28个月未见疾病复发迹象。
