Simick M K, Lilge L
Department of Medical Biophysics, University of Toronto, Ontario, Canada.
Br J Radiol. 2005 Nov;78(935):1009-17. doi: 10.1259/bjr/14696165.
Mammographic screening for early detection of breast cancer has proven valuable in improving breast cancer survival. However, breast cancer incidence is still increasing, and thus preventative oncology needs to receive more attention, with the goal of identifying women with increased risk of developing breast cancer in the future and offering them risk reduction interventions. Mammogram derived parenchymal density pattern has been shown by various authors to provide a high odds ratio for breast cancer. Near-infrared optical transillumination spectroscopy was employed to determine physiological properties of the breast tissue to quantify differences in women with low or high breast cancer risk. Specifically in this study, women who had a recent mammogram underwent examination of their breast tissue by optical transillumination spectroscopy. Areas of adipose and glandular tissues which give rise to mammographic density patterns also have characteristic optical transillumination spectra. Correlation between optical transillumination spectroscopy and mammographic density pattern was established using partial least squares analysis. Results show that predicted tissue density based on optical transillumination spectroscopy correlates with mammographic observed tissue density, with a Spearman Rank correlation coefficient of 0.72. This suggests that optical transillumination spectroscopy may be a promising tool to quantify and monitor changes in breast cancer risk.
乳腺钼靶筛查用于早期发现乳腺癌，已被证明在提高乳腺癌生存率方面具有重要价值。然而，乳腺癌发病率仍在上升，因此预防性肿瘤学需要得到更多关注，目标是识别未来患乳腺癌风险增加的女性，并为她们提供降低风险的干预措施。多位作者已表明，乳腺钼靶得出的实质密度模式对乳腺癌具有较高的比值比。采用近红外光透照光谱法来测定乳腺组织的生理特性，以量化乳腺癌低风险或高风险女性之间的差异。具体而言，在本研究中，近期进行过乳腺钼靶检查的女性接受了光透照光谱法对其乳腺组织的检查。产生乳腺钼靶密度模式的脂肪组织和腺组织区域也具有特征性的光透照光谱。使用偏最小二乘法分析建立了光透照光谱法与乳腺钼靶密度模式之间的相关性。结果表明，基于光透照光谱法预测的组织密度与乳腺钼靶观察到的组织密度相关，斯皮尔曼等级相关系数为0.72。这表明光透照光谱法可能是一种有前景的工具，可用于量化和监测乳腺癌风险的变化。
