Kim Jie Ae, Ahn Hyun Joo
Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 135-710, 50 Ilwon-dong, Kangnam-ku, Seoul, Korea.
Can J Anaesth. 2005 Nov;52(9):958-62. doi: 10.1007/BF03022058.
Hypobaric local anesthetics for total hip replacement (THR) have potential advantages related to body position and differential block. However, the dose requirements of hypobaric local anesthetics for THR have not been clearly established. Therefore, we undertook a dose-response study of hypobaric tetracaine for THR.
In a randomized, controlled, and double-blinded manner, three groups of 20 patients each undergoing THR received spinal anesthesia using either 10, 12, or 14 mg of 0.2% hypobaric tetracaine in a lateral decubitus position, with the operated side up. Adequate anesthesia was defined as: 1) upper sensory block between T10 and T4; 2) motor block of modified Bromage scale 2 or 3; and 3) time to sensory remission to the L2 level of more than three hours.
The number of patients who achieved adequate sensory and motor block levels was similar amongst the three groups. However, all patients who received 14 mg had a sensory remission time to L2 of more than three hours while only 30% of the patients in the 12 mg group and no patient in the 10 mg group had the same remission time. A significant differential block was observed between the non-dependent and the dependent sides, but the degree of differential block was not different between the groups.
10 to 14 mg of 0.2% hypobaric tetracaine achieved similar and adequate block levels, but different regression times. To ensure complete sensory block duration for THR, we recommend using 14 mg of 0.2% hypobaric tetracaine.
用于全髋关节置换术(THR)的低压局部麻醉药在体位和差异阻滞方面具有潜在优势。然而,THR中低压局部麻醉药的剂量需求尚未明确确定。因此,我们进行了一项关于低压丁卡因用于THR的剂量反应研究。
以随机、对照和双盲方式,三组各20例接受THR的患者在侧卧位且手术侧在上的情况下接受脊髓麻醉,分别使用10mg、12mg或14mg的0.2%低压丁卡因。充分麻醉定义为:1)T10至T4之间的上感觉阻滞;2)改良布罗麻量表2级或3级的运动阻滞;3)感觉恢复至L2水平的时间超过三小时。
三组中达到充分感觉和运动阻滞水平的患者数量相似。然而,所有接受14mg的患者感觉恢复至L2的时间超过三小时,而12mg组中只有30%的患者以及10mg组中没有患者有相同的恢复时间。在非依赖侧和依赖侧之间观察到明显的差异阻滞,但各组之间差异阻滞的程度没有差异。
10至14mg的0.2%低压丁卡因可达到相似且充分的阻滞水平,但消退时间不同。为确保THR的完全感觉阻滞持续时间,我们建议使用14mg的0.2%低压丁卡因。