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腹侧被盖区γ-氨基丁酸能受体对大鼠吗啡诱导的条件性位置偏爱表达的不同影响

Different effects of GABAergic receptors located in the ventral tegmental area on the expression of morphine-induced conditioned place preference in rat.

作者信息

Sahraei Hedayat, Amiri Yar-Ali, Haeri-Rohani Ali, Sepehri Houri, Salimi Seyed Hossein, Pourmotabbed Ali, Ghoshooni Hassan, Zahirodin Ali, Zardooz Homeira

机构信息

Department of Physiology and Biophysics, School of Medicine and Behavioral Sciences Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Araj st., Niavaran, Tehran, Iran.

出版信息

Eur J Pharmacol. 2005 Nov 7;524(1-3):95-101. doi: 10.1016/j.ejphar.2005.09.012. Epub 2005 Oct 25.

DOI:10.1016/j.ejphar.2005.09.012
PMID:16253224
Abstract

In the present study, an unbiased conditioned place preference paradigm was used to study the effects of intra-ventral tegmental area injections of Gama-amino-butyric acid (GABA)-A and B (GABA(A) and GABA(B)) receptor agonists and antagonists on the expression of morphine-induced conditioned place preference (CPP) in rats. Subcutaneous (s.c.) injections of morphine sulfate (5 mg/kg) induced CPP. Intra-ventral tegmental area administration of the GABA(A) receptor agonist, muscimol (6 microg/rat) reduced the expression of morphine-induced CPP. Muscimol (25 microg/rat) increased the expression of CPP induced by morphine. A reduction of the expression of morphine-induced CPP was observed on intra-ventral tegmental area injection of GABA(A) receptor antagonist bicuculline (25 microg/rat). Bicuculline (10 microg/rat) increased the expression of CPP induced by morphine. Baclofen (12 microg/rat) increased where as (19 and 25 microg/rat) reduced the expression of morphine-induced CPP. Injection of CGP38345 (10, 19, 25 and 50 microg/rat) into the ventral tegmental area significantly reduced the expression of CPP induced by morphine. It is concluded that GABA(A) and GABA(B) receptor subtypes within the ventral tegmental area may have different effects on the expression of morphine-induced CPP.

摘要

在本研究中，采用无偏倚的条件性位置偏爱范式，研究向大鼠腹侧被盖区注射γ-氨基丁酸（GABA）-A和B（GABA(A)和GABA(B)）受体激动剂及拮抗剂对吗啡诱导的条件性位置偏爱（CPP）表达的影响。皮下注射硫酸吗啡（5毫克/千克）可诱导CPP。向腹侧被盖区注射GABA(A)受体激动剂蝇蕈醇（6微克/只大鼠）可降低吗啡诱导的CPP的表达。蝇蕈醇（25微克/只大鼠）可增加吗啡诱导的CPP的表达。向腹侧被盖区注射GABA(A)受体拮抗剂荷包牡丹碱（25微克/只大鼠）可观察到吗啡诱导的CPP表达降低。荷包牡丹碱（10微克/只大鼠）可增加吗啡诱导的CPP的表达。巴氯芬（12微克/只大鼠）可增加，而（19微克/只大鼠和25微克/只大鼠）可降低吗啡诱导的CPP的表达。向腹侧被盖区注射CGP38345（10微克/只大鼠、19微克/只大鼠、25微克/只大鼠和50微克/只大鼠）可显著降低吗啡诱导的CPP的表达。得出的结论是，腹侧被盖区内的GABA(A)和GABA(B)受体亚型对吗啡诱导的CPP的表达可能有不同影响。

相似文献

[1]
Different effects of GABAergic receptors located in the ventral tegmental area on the expression of morphine-induced conditioned place preference in rat.

Eur J Pharmacol. 2005-11-7

[2]
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[6]
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[9]
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[10]
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引用本文的文献

[1]
Morphine-induced apoptosis in the ventral tegmental area and hippocampus after the development but not extinction of reward-related behaviors in rats.

Cell Mol Neurobiol. 2013-11-27

[2]
Regional mRNA expression of GABAergic receptor subunits in brains of C57BL/6J and 129P3/J mice: strain and heroin effects.

Brain Res. 2013-5-31

[3]
The Role of GABAB Receptors in Morphine Self-Administration.

Int J Prev Med. 2013-2

[4]
Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats.

J Neurosci. 2012-9-19

[5]
Identification of rat ventral tegmental area GABAergic neurons.

PLoS One. 2012-7-31

[6]
Differential involvement of GABAA and GABAB receptors in propofol self-administration in rats.

Acta Pharmacol Sin. 2011-10-10

[7]
Enhanced tyrosine hydroxylase phosphorylation in the nucleus accumbens and nucleus tractus solitarius-A2 cell group after morphine-conditioned place preference.

Naunyn Schmiedebergs Arch Pharmacol. 2010-10-6

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