伽玛刀放射外科治疗海绵窦转移瘤及侵犯
Gamma knife radiosurgery for cavernous sinus metastases and invasion.
作者信息
Iwai Yoshiyasu, Yamanaka Kazuhiro, Yoshimura Masaki
机构信息
Department of Neurosurgery, Osaka City General Hospital, Osaka 534-0021, Japan.
出版信息
Surg Neurol. 2005 Nov;64(5):406-10; discussion 410. doi: 10.1016/j.surneu.2004.12.021.
BACKGROUND
We evaluated the efficacy of gamma knife radiosurgery for cavernous sinus metastases and invasion.
METHOD
We treated and followed up 21 patients with cavernous sinus metastases and invasion using gamma knife radiosurgery. Nine of these patients had nasopharyngeal cancer, and 12 had distant metastases from other cancers. The volume of tumors ranged from 2.9 to 50.0 (median 9.9) mL. and the radiation dose to the tumor margin was 10 to 21 (median 14) Gy.
RESULTS
The median follow-up period was 9 months. Clinical symptoms were improved in 48% of the patients after treatment, and tumor growth control was obtained in 67% of the patients at their final follow-up. The actual 1- and 2-year tumor growth control rates were 68% and 43%, respectively. The mean survival time was 13 months. No patient had radiation injury.
CONCLUSION
Gamma knife radiosurgery is a very useful therapeutic option for the treatment of cavernous sinus metastases and invasion, either as initial treatment or as an adjunct treatment for recurrences even in preirradiated patients.
背景
我们评估了伽玛刀放射外科治疗海绵窦转移瘤及侵犯的疗效。
方法
我们采用伽玛刀放射外科治疗并随访了21例海绵窦转移瘤及侵犯患者。其中9例为鼻咽癌患者，12例为其他癌症的远处转移患者。肿瘤体积为2.9至50.0（中位数9.9）毫升，肿瘤边缘的放射剂量为10至21（中位数14）Gy。
结果
中位随访期为9个月。治疗后48%的患者临床症状得到改善，末次随访时67%的患者肿瘤生长得到控制。实际1年和2年肿瘤生长控制率分别为68%和43%。平均生存时间为13个月。无患者发生放射性损伤。
结论
伽玛刀放射外科是治疗海绵窦转移瘤及侵犯的一种非常有用的治疗选择，无论是作为初始治疗还是作为复发患者（即使是曾接受过放疗的患者）的辅助治疗。
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