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deceased供体肾脏移植的分配:慢性肾脏病患者的观点

Allocation of deceased donor kidneys for transplantation: opinions of patients with CKD.

作者信息

Geddes Colin C, Rodger R Stuart C, Smith Christopher, Ganai Anita

机构信息

Renal Unit, Western Infirmary, University of Glasgow, Scotland.

出版信息

Am J Kidney Dis. 2005 Nov;46(5):949-56. doi: 10.1053/j.ajkd.2005.07.031.

Abstract

BACKGROUND

Deceased donor kidney allocation schemes are designed to balance optimal utility with equity of access. The aim of this single-center survey is to seek patient opinion about the relative importance of factors used to determine the optimal transplant recipient in kidney allocation schemes.

METHODS

In each of 8 scenarios, participants were invited to select which 1 of 2 hypothetical patients should receive a kidney.

RESULTS

Two hundred thirty-two of 295 invited patients (78.6%) completed the questionnaire: 104 of 153 invited hemodialysis patients (68.0%) and 128 of 142 invited patients with functioning transplants (90.1%). Only 6.0% of participants agreed with current UK Transplant (UKT) and United Network for Organ Sharing (UNOS) allocation to a patient not yet on dialysis therapy who had been on the transplant waiting list longer than a patient already on dialysis therapy. Only 24.6% of participants agreed with the UKT and UNOS schemes that the transplant survival advantage associated with HLA matching warranted allocation of a kidney to a patient who had been waiting 2 years in preference to a patient waiting 7 years. Participants also were opposed to the use of recipient age and balance of exchange agreements (that reward centers with high rates of organ retrieval). The majority agreed with UKT and UNOS that recipient sex should not be used to allocate kidneys and allocation should favor recipients who have waited longer.

CONCLUSION

Patients disagreed with several aspects of current allocation systems. Analysis of patient opinion should be taken into consideration when attempting to optimize the use of this scarce health resource.

摘要

背景

已故捐赠者肾脏分配方案旨在平衡最佳效用与获取公平性。这项单中心调查的目的是征求患者对于肾脏分配方案中用于确定最佳移植受者的因素的相对重要性的看法。

方法

在8种情景中的每一种情景下,邀请参与者选择2名假设患者中的哪1名应该接受肾脏。

结果

295名受邀患者中有232名(78.6%)完成了问卷:153名受邀血液透析患者中有104名(68.0%),142名受邀有功能移植的患者中有128名(90.1%)。只有6.0%的参与者同意英国移植组织(UKT)和器官共享联合网络(UNOS)目前将肾脏分配给尚未接受透析治疗但在移植等待名单上的时间比已接受透析治疗的患者更长的患者的做法。只有24.6%的参与者同意UKT和UNOS的方案,即与人类白细胞抗原(HLA)匹配相关的移植生存优势保证将肾脏分配给等待2年的患者而不是等待7年的患者。参与者也反对使用受者年龄和交换协议平衡(奖励器官获取率高的中心)。大多数人同意UKT和UNOS的观点,即受者性别不应被用于分配肾脏,分配应有利于等待时间更长的受者。

结论

患者不同意当前分配系统的几个方面。在试图优化这种稀缺卫生资源的使用时,应考虑对患者意见的分析。

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