中华猕猴桃根中的细胞毒性酚类成分。

Cytotoxic phenolic constituents from the root of Actinidia chinensis.

作者信息

Chang Jun, Case Ryan

机构信息

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China [corrected]

出版信息

Planta Med. 2005 Oct;71(10):955-9. doi: 10.1055/s-2005-871225.

DOI:10.1055/s-2005-871225

PMID:16254829

Abstract

Twelve phenolic compounds, including four novel skeleton phenolic compounds, planchols A-D (1-4), together with four pairs of isomeric flavanoids (5-12) were isolated from the root of Actinidia chinensis Planch (Actinidiaceae). Their structures were elucidated by spectroscopic analysis and chemical evidence. The structure of 1 was further confirmed by a single-crystal X-ray diffraction determination. Moreover, it was found that 1 and 2 showed remarkable cytotoxic activity against P-388 and A-549 cell lines.

摘要

从中华猕猴桃（猕猴桃科）的根中分离出12种酚类化合物，包括4种具有新型骨架的酚类化合物，即猕猴桃醇A-D（1-4），以及4对异构黄酮（5-12）。通过光谱分析和化学证据阐明了它们的结构。1的结构通过单晶X射线衍射测定进一步得到证实。此外，发现1和2对P-388和A-549细胞系显示出显著的细胞毒性活性。