全身MRI和FDG-PET对一名尤因肉瘤患者分期及治疗反应评估的影响

Impact of whole-body MRI and FDG-PET on staging and assessment of therapy response in a patient with Ewing sarcoma.

作者信息

Furth C, Amthauer H, Denecke T, Ruf J, Henze G, Gutberlet M

机构信息

Klinik für Strahlenheilkunde, Bereiche Diagnostische Radiologie und Nuklearmedizin, Charité-Universitätsmedizin, Berlin, Germany.

出版信息

Pediatr Blood Cancer. 2006 Oct 15;47(5):607-11. doi: 10.1002/pbc.20662.

DOI:10.1002/pbc.20662

PMID:16261559

Abstract

In patients with Ewing sarcoma, precise staging is not only crucial for the therapeutic regimen but also for a reliable evaluation of response to therapy. We report on a 15-year-old girl with metastatic spread of a Ewing sarcoma who, apart from conventional staging by bone scan, chest X-ray and CT, was subsidiary examined by FDG-PET and whole-body MRI before and after chemotherapy. Both modalities detected more bone lesions than the bone scan, which led to an altered strategy for radiotherapy. Both examinations might be a great asset to stage-adjusted therapy regimens, ultimately influencing patient outcome.

摘要

在尤因肉瘤患者中，精确分期不仅对治疗方案至关重要，而且对于可靠评估治疗反应也很关键。我们报告了一名15岁患有尤因肉瘤转移的女孩，除了通过骨扫描、胸部X光和CT进行传统分期外，在化疗前后还通过氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）和全身磁共振成像（MRI）进行了辅助检查。这两种检查方式检测到的骨病变都比骨扫描更多，这导致了放疗策略的改变。这两种检查对于根据分期调整的治疗方案可能是一项重要资产，最终会影响患者的治疗结果。