Saarela Tanja, Hiltunen Mikko, Helisalmi Seppo, Heinonen Seppo, Laakso Markku
Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland.
Gynecol Obstet Invest. 2006;61(3):124-7. doi: 10.1159/000089482. Epub 2005 Nov 2.
Preeclampsia is a common hereditary disease with unclear aetiology and various genetic and environmental components. We wanted to determine whether genetic variability in the gene encoding plasma cell membrane glycoprotein-1 (PC-1) contributes to individual susceptibility to the development of preeclampsia.
The case-control study involved 133 women with preeclampsia and 115 healthy controls. They were genotyped for the K121Q polymorphism in the PC-1 gene. chi(2) analysis was used to assess genotype and allele frequency differences between preeclamptic and control women.
The frequency of the PC-1 gene 121K allele was found to be equal in the two groups, being 90.2% among women with preeclampsia and 90.4% among controls (p = 0.937; OR = 1.024; 95% CI = 0.564-1.861). Also the genotype distribution of the PC-1 K121Q polymorphism was similar (p = 0.516) in the preeclamptic and control groups.
The K121Q polymorphism of the PC-1 gene is unlikely to be a major genetic factor predisposing to preeclampsia in Finnish women.
先兆子痫是一种常见的遗传性疾病，其病因不明，涉及多种遗传和环境因素。我们想确定编码浆细胞膜糖蛋白-1（PC-1）的基因中的遗传变异性是否会导致个体患先兆子痫的易感性。
这项病例对照研究纳入了133例先兆子痫女性和115例健康对照者。对她们进行PC-1基因K121Q多态性的基因分型。采用卡方分析评估先兆子痫女性和对照女性之间的基因型和等位基因频率差异。
发现两组中PC-1基因121K等位基因的频率相等，先兆子痫女性中为90.2%，对照者中为90.4%（p = 0.937；OR = 1.024；95% CI = 0.564 - 1.861）。先兆子痫组和对照组中PC-1 K121Q多态性的基因型分布也相似（p = 0.516）。
在芬兰女性中，PC-1基因的K121Q多态性不太可能是先兆子痫的主要遗传易患因素。
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