在发育中的视网膜中，Pea3表达受成纤维细胞生长因子（FGF）信号调控。
Pea3 expression is regulated by FGF signaling in developing retina.
作者信息
McCabe Kathryn Leigh, McGuire Chris, Reh Thomas A
机构信息
Department of Biology, California Institute of Technology, Pasadena, California 91125, USA.
出版信息
Dev Dyn. 2006 Feb;235(2):327-35. doi: 10.1002/dvdy.20631.
Abstract
FGF signaling has been implicated as an important regulator of retinal development. As a first step in characterizing potential downstream targets of FGF signaling in the retina, we have analyzed expression of Pea3, a member of the Pea3 class of Ets-domain transcription factors, in the developing eye. We find that Pea3 is expressed in the developing retina, and its transcription is regulated by FGF receptor activation. In addition, FGF signaling activates Cath5, a gene necessary for retinal ganglion cell differentiation. These results suggest that FGF signaling via MAPK up-regulates transcription factors that in turn control retinal ganglion cell differentiation.
摘要
成纤维细胞生长因子（FGF）信号传导被认为是视网膜发育的重要调节因子。作为表征视网膜中FGF信号传导潜在下游靶点的第一步，我们分析了Ets结构域转录因子Pea3家族成员Pea3在发育中的眼睛中的表达。我们发现Pea3在发育中的视网膜中表达，其转录受FGF受体激活的调节。此外，FGF信号传导激活Cath5，这是视网膜神经节细胞分化所必需的基因。这些结果表明，通过丝裂原活化蛋白激酶（MAPK）的FGF信号传导上调转录因子，进而控制视网膜神经节细胞的分化。
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