Ryder Kathryn M, Shorr Ronald I, Bush Andrew J, Kritchevsky Stephen B, Harris Tamara, Stone Katie, Cauley Jane, Tylavsky Frances A
Department of Medicine, Health Science Center, University of Tennessee, Memphis, Tennessee 38105, USA.
J Am Geriatr Soc. 2005 Nov;53(11):1875-80. doi: 10.1111/j.1532-5415.2005.53561.x.
To determine whether magnesium intake from supplemental and dietary sources is associated with bone mineral density (BMD) in older men and women.
Cross-sectional.
Memphis, Tennessee, and Pittsburgh, Pennsylvania.
Two thousand thirty-eight older black and white men and women aged 70 to 79 at baseline enrolled in the Health, Aging and Body Composition Study.
Dietary intake of magnesium was assessed using a semiquantitative food frequency questionnaire, and supplement data were collected based on a medication inventory. BMD of the whole body was obtained using a fan-beam densitometer. Additional covariates included age, body mass index (BMI), smoking status, alcohol use, physical activity, estrogen use, and supplemental calcium (Ca) and vitamin D use.
In white, but not black, men and women, magnesium intake was positively associated with BMD of the whole body after adjustment for age, self-report of osteoporosis or fracture in adulthood, caloric intake, Ca and vitamin D intake, BMI, smoking status, alcohol intake, physical activity, thiazide diuretic use, and estrogen use in women (P=.05 for men and P=.005 for women). BMD was 0.04 g/cm2 higher in white women and 0.02 g/cm2 higher in white men in the highest than in the lowest quintile of magnesium intake.
Greater magnesium intake was significantly related to higher BMD in white women and men. The lack of association observed in black women and men may be related to differences in Ca regulation or in nutrient reporting.
确定来自补充剂和饮食来源的镁摄入量是否与老年男性和女性的骨矿物质密度（BMD）相关。
横断面研究。
田纳西州孟菲斯市和宾夕法尼亚州匹兹堡市。
2038名年龄在70至79岁之间的老年黑人和白人男性及女性，他们在基线时参加了健康、衰老和身体成分研究。
使用半定量食物频率问卷评估镁的饮食摄入量，并根据药物清单收集补充剂数据。使用扇形束密度计获得全身的骨矿物质密度。其他协变量包括年龄、体重指数（BMI）、吸烟状况、饮酒情况、身体活动、雌激素使用情况以及补充钙（Ca）和维生素D的使用情况。
在白人男性和女性中（黑人中未发现此关联），在调整年龄、成年期骨质疏松或骨折的自我报告、热量摄入、钙和维生素D摄入量、BMI、吸烟状况、酒精摄入量、身体活动、噻嗪类利尿剂使用情况以及女性雌激素使用情况后，镁摄入量与全身骨矿物质密度呈正相关（男性P = 0.05，女性P = 0.005）。在镁摄入量最高的五分位数组中，白人女性的骨矿物质密度比最低五分位数组高0.04g/cm²，白人男性高0.02g/cm²。
较高的镁摄入量与白人女性和男性较高的骨矿物质密度显著相关。在黑人女性和男性中未观察到这种关联可能与钙调节或营养报告方面的差异有关。
