Yu Zhou, Li Tao, Cai Tao, Zhao Jindong, Luo Jingchu
College of Life Sciences, National Laboratory of Protein Engineering and Plant Genetic Engineering, Centre of Bioinformatics, Peking University, Beijing 100871, China.
Wei Sheng Wu Xue Bao. 2003 Dec;43(6):805-8.
A Microbe Genome Annotation Platform (MGAP) was developed and applied to the cynobacterium PCC7002 genome annotation. Various bioinformatics software tools from sequence analysis to gene identification and function prediction were implemented in MGAP. Protein sequence databases SWISSPROT and PDBseq, protein information resource InterPro and COG were also integrated in the platform. The web interface of MGAP has the functionality to display a circular map of gene distribution and GC contents throughout the genome. Detailed information such as the DNA and protein sequence, the location of genes on chromosomes can be viewed by clicking the corresponding object within the map. MGAP is based on a PC/Linux system affordable for small biological laboratories and has the advantage of using free software tools including MySQL, Apache and Perl.
开发了一种微生物基因组注释平台（MGAP）并将其应用于蓝细菌PCC7002的基因组注释。MGAP中实现了从序列分析到基因识别和功能预测的各种生物信息学软件工具。蛋白质序列数据库SWISSPROT和PDBseq、蛋白质信息资源InterPro和COG也集成在该平台中。MGAP的网络界面具有显示整个基因组基因分布和GC含量的环形图的功能。通过点击图中的相应对象，可以查看诸如DNA和蛋白质序列、基因在染色体上的位置等详细信息。MGAP基于小型生物实验室可负担得起的PC/ Linux系统，并且具有使用包括MySQL、Apache和Perl在内的免费软件工具的优势。
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