[利用酵母细胞对苯乙酮和氯苯乙酮进行立体选择性还原制备手性醇]
[Preparation of chiral alcohol by stereoselective reduction of acetophenone and chloroacetophenone with yeast cells].
作者信息
Ou Zhimin, Wu Jianping, Yang Lirong, Cen Peilin
机构信息
Institute of Biochemical Engineering, College of Material Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China.
出版信息
Wei Sheng Wu Xue Bao. 2003 Aug;43(4):523-6.
Four strains of microorganisms which have activity of chloroacetophenone reduction were screened, in which Saccharomyces cerevisiae B5 showed the highest activity and good stereoselectivity. This strains showed different activity on the reduction of various substrates in the following order: 2'-chloroacetophenone > 2-chloromethylacetophenone > 4'-chloroacetophenone > 3'-chloroacetophenone > acetophenone. Ethanol is the best cosubstrate and its optimal concentration is 5%.
筛选出了四株具有氯苯乙酮还原活性的微生物，其中酿酒酵母B5表现出最高的活性和良好的立体选择性。该菌株对各种底物的还原活性顺序如下：2'-氯苯乙酮>2-氯甲基苯乙酮>4'-氯苯乙酮>3'-氯苯乙酮>苯乙酮。乙醇是最佳共底物，其最佳浓度为5%。
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