正常皮肤成纤维细胞与瘢痕疙瘩病变中央和周边区域来源的成纤维细胞之间转化生长因子-β/Smad信号传导的比较
Comparison of transforming growth factor-beta/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions.
作者信息
Tsujita-Kyutoku Miki, Uehara Norihisa, Matsuoka Yoichiro, Kyutoku Shigeo, Ogawa Yutaka, Tsubura Airo
机构信息
Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan.
出版信息
In Vivo. 2005 Nov-Dec;19(6):959-63.
BACKGROUND
Keloids are benign proliferations of fibroblasts, but their exact etiology and molecular pathogenesis are unknown.
MATERIALS AND METHODS
Fibroblasts were isolated from the central and peripheral regions of keloids, and the growth behavior and molecular characteristics of the keloid fibroblasts were compared with those of age-adjusted normal dermal fibroblasts.
RESULTS
Central (but not peripheral) keloid fibroblasts exhibited significantly increased growth and high levels of expression of transforming growth factor-beta (TGF-beta) receptor 1 and Smad 2/3.
CONCLUSION
Proliferation of central keloid fibroblasts, which results in keloid formation, appears to mainly involve the TGF-beta/Smad pathway.
背景
瘢痕疙瘩是成纤维细胞的良性增殖，但确切病因和分子发病机制尚不清楚。
材料与方法
从瘢痕疙瘩的中央和周边区域分离成纤维细胞，并将瘢痕疙瘩成纤维细胞的生长行为和分子特征与年龄匹配的正常真皮成纤维细胞进行比较。
结果
中央（而非周边）瘢痕疙瘩成纤维细胞表现出显著增强的生长以及转化生长因子-β（TGF-β）受体1和Smad 2/3的高表达水平。
结论
导致瘢痕疙瘩形成的中央瘢痕疙瘩成纤维细胞增殖似乎主要涉及TGF-β/Smad信号通路。
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