咖啡酸苯乙酯改善链脲佐菌素诱导的糖尿病大鼠中胰岛素样生长因子的分泌变化和基因表达。

Caffeic acid phenethyl ester ameliorates changes in IGFs secretion and gene expression in streptozotocin-induced diabetic rats.

作者信息

Park Soo Hyun, Min Tae Sun

机构信息

Department of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, South Korea.

出版信息

Life Sci. 2006 Mar 6;78(15):1741-7. doi: 10.1016/j.lfs.2005.08.011. Epub 2005 Nov 8.

DOI:10.1016/j.lfs.2005.08.011

PMID:16277997

Abstract

The protective effect of caffeic acid phenethyl ester (CAPE) against diabetes-induced alteration of IGFs protein and gene expression was investigated in serum, liver, heart, and kidney. In the present study, diabetic rats exhibited the decrease of IGF-I content in serum, liver and heart but the increase of that in kidney and CAPE blocked them. Diabetic rats also manifested the increase of IGF-II content in serum, liver, heart, and kidney and CAPE prevented them. CAPE prevented the diabetes-induced decrease of liver IGF-I mRNA and IGF-II mRNA, which is similar to pattern of IGFs mRNA in kidney. Moreover, diabetic rats exhibited the decrease of heart IGF-I mRNA but the increase of IGF-II mRNA and CAPE blocked them. In conclusion, CAPE, in part, prevented diabetes-induced alteration of IGF-I and IGF-II protein and gene expression in liver, heart, and kidney in rats.

摘要

研究了咖啡酸苯乙酯（CAPE）对糖尿病诱导的血清、肝脏、心脏和肾脏中胰岛素样生长因子（IGFs）蛋白及基因表达变化的保护作用。在本研究中，糖尿病大鼠血清、肝脏和心脏中的IGF-I含量降低，而肾脏中的IGF-I含量升高，CAPE可阻止这些变化。糖尿病大鼠血清、肝脏、心脏和肾脏中的IGF-II含量也升高，CAPE可预防这些变化。CAPE可预防糖尿病诱导的肝脏IGF-I mRNA和IGF-II mRNA降低，这与肾脏中IGFs mRNA的模式相似。此外，糖尿病大鼠心脏IGF-I mRNA降低，但IGF-II mRNA升高，CAPE可阻止这些变化。总之，CAPE部分预防了糖尿病诱导的大鼠肝脏、心脏和肾脏中IGF-I和IGF-II蛋白及基因表达的改变。