99m锝- TRODAT - 1单光子发射计算机断层扫描研究早期帕金森病和特发性震颤

99mTc-TRODAT-1 SPECT study in early Parkinson's disease and essential tremor.

作者信息

Wang J, Jiang Y-P, Liu X-D, Chen Z-P, Yang L-Q, Liu C-J, Xiang J-D, Su H-L

机构信息

Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.

出版信息

Acta Neurol Scand. 2005 Dec;112(6):380-5. doi: 10.1111/j.1600-0404.2005.00517.x.

DOI:10.1111/j.1600-0404.2005.00517.x

PMID:16281920

Abstract

OBJECTIVE

The clinical differentiation between early Parkinson's disease (PD) and essential tremor (ET) could be difficult, therefore, the aim of this study was to investigate 99mTc-TRODAT-1 SPECT as an applicable tool in this field.

METHODS

99mTc-TRODAT-1 single photon emission computed tomography (SPECT) was performed in 10 healthy volunteers, 27 patients with idiopathic PD (Hoehn and Yahr 1-1.5) and 12 patients with ET. The ratio of striatal (99m)Tc-TRODAT-1 binding was calculated as the index of (striatum - occipital cortex)/occipital cortex.

RESULTS

Compared with the striatal 99mTc-TRODAT-1 uptake in the ET group (0.49 +/- 0.07) or healthy controls (0.54 +/- 0.18), there was a significant decrease in the bilateral striatums of early PD, with a greater reduction in the contralateral striatum (0.27 +/- 0.08) than ipsilateral one (0.36 +/- 0.10, P < 0.01). Its sensitivity and specificity of differentiating early PD from ET was 96.4% and 91.7% respectively.

CONCLUSION

99mTc-TRODAT-1 SPECT can detect the dysfunction of nigrostriatal system in patients with early PD and provided a feasible tool to help differentiate early PD from ET.

摘要

目的

早期帕金森病（PD）与特发性震颤（ET）的临床鉴别可能存在困难，因此，本研究旨在探讨99mTc-TRODAT-1单光子发射计算机断层扫描（SPECT）作为该领域一种适用工具的情况。

方法

对10名健康志愿者、27例特发性PD患者（Hoehn和Yahr分级为1 - 1.5级）及12例ET患者进行99mTc-TRODAT-1单光子发射计算机断层扫描（SPECT）检查。计算纹状体（99m）Tc-TRODAT-1结合率，以（纹状体 - 枕叶皮质）/枕叶皮质作为指标。

结果

与ET组（0.49±0.07）或健康对照组（0.54±0.18）的纹状体99mTc-TRODAT-1摄取情况相比，早期PD患者双侧纹状体摄取显著降低，对侧纹状体降低程度（0.27±0.08）大于同侧（0.36±0.10，P<0.01）。其鉴别早期PD与ET的敏感性和特异性分别为96.4%和91.7%。