Murray Rachael Z, Kay Jason G, Sangermani Daniele G, Stow Jennifer L
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
Science. 2005 Dec 2;310(5753):1492-5. doi: 10.1126/science.1120225. Epub 2005 Nov 10.
Membrane traffic in activated macrophages is required for two critical events in innate immunity: proinflammatory cytokine secretion and phagocytosis of pathogens. We found a joint trafficking pathway linking both actions, which may economize membrane transport and augment the immune response. Tumor necrosis factor alpha (TNFalpha) is trafficked from the Golgi to the recycling endosome (RE), where vesicle-associated membrane protein 3 mediates its delivery to the cell surface at the site of phagocytic cup formation. Fusion of the RE at the cup simultaneously allows rapid release of TNFalpha and expands the membrane for phagocytosis.
促炎细胞因子分泌和病原体吞噬作用。我们发现了一条连接这两种作用的联合运输途径，这可能会节省膜运输并增强免疫反应。肿瘤坏死因子α（TNFα）从高尔基体运输到再循环内体（RE），在那里囊泡相关膜蛋白3介导其在吞噬杯形成部位递送至细胞表面。RE在吞噬杯处的融合同时允许TNFα快速释放，并扩展膜以进行吞噬作用。
